Blog
Notes and updates. For the reference material, see the guides.
- Immune & Systemic Regulators: Thymosin Alpha-1, Thymalin, VIP, and Oxytocin What trials show for Thymosin Alpha-1, thymalin, VIP (aviptadil), oxytocin and glutathione injections, with UK licensing status and reconstitution maths.
- Melanocortin Receptor Agonism: Melanotan I vs. Melanotan II vs. PT-141 (Bremelanotide) How Melanotan I, Melanotan II and PT-141 (bremelanotide) differ in receptor action, licensing and safety, including what the male PT-141 trials tested.
- Hypothalamic-Pituitary-Gonadal Support: hCG, Kisspeptin-10, and Fertility Protocols How hCG, Kisspeptin-10, Gonal-F and triptorelin act on the reproductive axis, their licensed doses, and the reconstitution maths for a 5,000 IU hCG vial.
- Cosmetic & Dermal Peptides: GHK-Cu, Snap-8, and the “Glow” Blends What the evidence shows for GHK-Cu skin and hair effects, why Snap-8 is a topical cosmetic ingredient, and what the GLOW and KLOW blends actually contain.
- Semax and Selank: BDNF Upregulation vs GABAergic Anxiolysis How Semax and Selank differ, BDNF/TrkB signalling versus GABAergic anxiolysis, the Russian trial data, the intranasal route and UK legal status.
- Epithalon and Pinealon: Bioregulator Peptides and the Telomere Claims Epithalon's telomerase claims, Pinealon's neuroprotection data, the weakness of the Russian evidence, and the epithalon protocol 10 days question.
- DSIP (Delta Sleep-Inducing Peptide): Evidence and Dosing Literature What DSIP is, why its sleep role is contested, the mixed human insomnia trials, and the dsip peptide dosage for sleep reported in the literature.
- Dihexa vs Adamax: Angiotensin IV Analogues and Vendor Compounds Dihexa's HGF/c-Met mechanism, the retracted rodent data and safety unknowns, and what the vendor compound Adamax (984 Da and 1032 Da) actually is.
- Exercise-Mimetic Compounds: SLU-332, AICAR, and 5-Amino-1MQ Mechanics What SLU-332 (SLU-PP-332), AICAR and 5-Amino-1MQ actually do: ERR, AMPK and NNMT mechanisms, the mouse doses behind "exercise in a pill", and WADA status.
- Mitochondrial Biogenesis: Examining MOTS-c and SS-31 Peptides MOTS-c and SS-31 explained: mouse data, the CB4211 human trial, elamipretide's 2025 FDA approval, trial doses and reconstitution maths for a 10 mg vial.